A Coherent Mechanistic Rationale for Additive Effects and Autoinductive Behavior in Proline-Mediated Reactions
نویسندگان
چکیده
Differences in the kinetic behavior of aldol reactions compared to aminoxylation and amination reactions are rationalized by consideration of the ratedetermining step in each case. Both autoinductive behavior and the rate-enhancing effect of additives are attributed to an effect on the enamine formation step.
منابع مشابه
Clarification of the role of water in proline-mediated aldol reactions.
The report by List, Lerner, and Barbas1 in 2000 of an intermolecular direct aldol reaction catalyzed by proline became an unexpected watershed for the field of organocatalysis.2-4 Pihko and co-workers4b,c were the first to observe significantly higher yields with addition of water to intermolecular aldol reactions, even allowing employment of stoichiometric substrate ratios in some cases. This ...
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